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CASE REPORT
Year : 2019  |  Volume : 6  |  Issue : 1  |  Page : 45-49

Paraneoplastic Systemic Sclerosis in a Patient with Metastatic Thymic Carcinoma


1 Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
2 Department of Rheumatology, National Taiwan University Hospital, Taipei, Taiwan
3 Department of Oncology, National Taiwan University Hospital, Taipei; Division of Hematology and Oncology, Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, Hsinchu, Taiwan

Correspondence Address:
Dr. Hung-Yang Kuo
Division of Hematology and Oncology, Department of Internal Medicine, National Taiwan University Hospital Hsin-Chu Branch, No. 25, Lane 442, Sec. 1, Jingguo Road, Hsinchu 300
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCRP.JCRP_8_18

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Thymic malignancies cause alterations in the immune system. Thymomas are known to be associated with paraneoplastic syndrome and autoimmunity, including myasthenia gravis, systemic lupus erythematosus, inappropriate antidiuretic hormone secretion, pure red cell aplasia, pernicious anemia, pemphigus, and autoimmune thyroid diseases. However, paraneoplastic syndrome has rarely been observed in patients with thymic carcinoma. The management of patients with paraneoplastic autoimmune disease is difficult, and treatment of the underlying malignancy is important. Herein, we present a case of thymic carcinoma who developed systemic sclerosis 3 years after the initial diagnosis during disease progression.


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