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CASE REPORT
Year : 2019  |  Volume : 6  |  Issue : 2  |  Page : 103-106

Pulmonary pleomorphic carcinoma harboring epidermal growth factor receptor mutation: Response to afatinib


1 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Egypt; Department of Oncology, King Fahad Hospital, Madinah, Saudi Arabia
2 Department of Oncology, King Fahad Hospital, Madinah, Saudi Arabia
3 Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Egypt
4 Department of Oncology, King Fahad Hospital, Madinah, Saudi Arabia; Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Suez Canal University, Egypt
5 Department of Clinical Pharmacology, Faculty of Medicine, Mansoura University, Egypt

Correspondence Address:
Dr. Abeer Hussien Anter
Department of Clinical Oncology and Nuclear Medicine, Faculty of Medicine, Mansoura University, Mansoura

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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCRP.JCRP_16_18

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Pulmonary pleomorphic carcinoma (PPC) of the lung is a rare type of non-small cell lung cancer, exhibiting aggressive behavior and resistance to chemotherapy. We report a case of a 56-year-old female, diagnosed with PPC of the lung at clinical Stage IV in July 2017. She underwent first-line chemotherapy. The disease progressed after 6 cycles of chemotherapy, and we shift to afatinib due to presence of epidermal growth factor receptor (EGFR) mutation in exon 19. We then started second-line treatment in the form of molecular targeted therapy (afatinib), to which she had a partial response. Hence, we recommend the evaluation of driver gene alterations such as EGFR in the treatment of advanced PPC.


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