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CASE REPORT
Year : 2019  |  Volume : 6  |  Issue : 3  |  Page : 140-146

Pathologic complete response to bevacizumab-FOLFIRI in metastatic colonic undifferentiated carcinoma with rhabdoid features


1 Department of Surgery, Division of Colorectal Surgery, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
2 Department of Pathology and Laboratory Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan
3 Department of Surgery, Division of Colorectal Surgery, Kaohsiung Veterans General Hospital, Kaohsiung; School of Medicine, Faculty of Medicine, National Yang-Ming University, Taipei, Taiwan

Correspondence Address:
Dr. Chao-Wen Hsu
Department of Surgery, Division of Colorectal Surgery, Kaohsiung Veterans General Hospital, No. 386, Dazhong 1st Road, Zuoying District, Kaohsiung City 81362
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCRP.JCRP_24_18

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Undifferentiated colorectal carcinoma with rhabdoid features is unusual, aggressive, and resistant to chemotherapy. Compared to rhabdoid phenotype, immunohistochemistry is a more reliable way of detecting undifferentiated colorectal carcinoma with rhabdoid features. An increasing number of studies have reported that defects in core subunits of the switch/sucrose-nonfermenting complex may play an important role in the formation of rhabdoid tumors. Herein, we report the first case, to the best of our knowledge, with a pathologic complete response after neoadjuvant chemotherapy. A 65-year-old Taiwanese female had carcinoma over the ascending colon and multiple metastases to mesenteric lymph nodes and peritoneum. The immunohistochemical findings resembled those of rhabdoid features. She had received neoadjuvant chemotherapy with bevacizumab plus irinotecan with leucovorin and 5-fluorouracil (modified FOLFIRI). Follow-up computed tomography and surgical specimens revealed a favorable outcome. The effectiveness of neoadjuvant multiagent therapy for this rare carcinoma may inspire future research of tumorigenesis and novel treatments.


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