• Users Online: 503
  • Print this page
  • Email this page
ORIGINAL ARTICLE
Year : 2019  |  Volume : 6  |  Issue : 4  |  Page : 179-183

Association between serum folate level and invasive cervical cancer at a university teaching hospital in South-West Nigeria


1 Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Idi-Araba, Lagos, Nigeria
2 Department of Obstetrics and Gynaecology, Lagos University Teaching Hospital, Idi-Araba; Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, Lagos, Nigeria
3 Division of Epidemiology and Biostatistics, School of Public Health, University of the Witwatersrand, Johannesburg, South Africa

Correspondence Address:
Dr. Kehinde S Okunade
Department of Obstetrics and Gynaecology, College of Medicine, University of Lagos, PMB 12003, Idi-Araba, Lagos
Nigeria
Login to access the Email id

Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCRP.JCRP_24_19

Rights and Permissions

Background: Cervical cancer is a common cause of cancer-related morbidity and mortality in developing countries. Serum folate may modify cancer risk through its role in DNA synthesis and methylation. Objective: To determine the association between serum folate levels and the occurrence of cervical cancer among women seen at a university teaching hospital in South-West Nigeria. Patients and Methods: This was an analytical cross-sectional study involving two groups of participants including 50 cases with invasive cervical cancer (ICC) and 50 controls with a normal cervix. Data analysis was performed between discrete baseline characteristics of the cases and controls using the Pearson's Chi-square test, whereas the mean serum folate levels of the cases and controls were compared using the independent sample t-test. P<0.05 was considered statistically significant. Results: There was no significant positive association between low serum folate and the occurrence of ICC (adjusted odds ratio: 2.99; P = 0.088). Conclusions: The findings of this study showed that low serum folate was not independently associated with an increased risk of ICC. However, a robust multicenter long-term longitudinal study will provide further evidence on the role of serum folate in the occurrence of ICC.


[FULL TEXT] [PDF]*
Print this article     Email this article
 Next article
 Previous article
 Table of Contents

 Similar in PUBMED
   Search Pubmed for
   Search in Google Scholar for
 Related articles
 Citation Manager
 Access Statistics
 Reader Comments
 Email Alert *
 Add to My List *
 * Requires registration (Free)
 

 Article Access Statistics
    Viewed319    
    Printed12    
    Emailed0    
    PDF Downloaded28    
    Comments [Add]    

Recommend this journal