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ORIGINAL ARTICLE
Year : 2020  |  Volume : 7  |  Issue : 1  |  Page : 11-16

Considering blood samples for early diagnosis of prostate cancer by evaluating prostate cancer antigen 3 expression values


1 Department of Medical Genetic, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2 Department of Biology, Islamic Azad University, East Tehran Branch, Tehran, Iran
3 Incubation Center for Pharmaceutical Technologies, Shahid Beheshti University of Medical Sciences, Azma Elixir Pazhooh Co., Tehran, Iran

Correspondence Address:
Dr. Maedeh Mashhadikhan
Incubation Center for Pharmaceutical Technologies, Shahid Beheshti University of Medical Sciences, Azma Elixir Pazhooh Co., Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCRP.JCRP_25_19

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Background: Prostate cancer antigen 3 (PCA3) is the most specific biomarker for an early diagnosis of prostate cancer (PCa), and it is routinely evaluated in urine samples. Recent investigations consider blood as a reliable source to determine PCA3 expression levels and fast diagnosis of PCa since in addition to bacterial and viral contaminations and the hygienic problems, if the area of the prostatic duct is not involved PCa, the obtained urine samples may not contain any cancerous cells. Materials and Methods: This study investigated blood expression values of the PCA3 gene in patients with PCa and multiple endocrine neoplasia compared with normal volunteers in an Iranian population. A total of 150 blood samples from three groups were assessed for PCA3 expression using real-time polymerase chain reaction. Prostate-specific antigen (PSA) serum levels, age, and family history of PCa were also analyzed. Results: PCA3 expression analysis showed a significant increase in PCa patients and in patients with PSA serum levels higher than 7 ng/ml (P = 0.005 and P= 0.0011, respectively). Analysis of blood samples from men with an older age and positive family history also showed significant PCA3 expression values. Results of this study suggests that evaluating PCA3 gene expression in blood samples is an adequate method for an early diagnosis of PCa. The decision to perform a prostate biopsy should be made more cautiously in patients with a PSA serum level between 4 and 7 ng/ml. Patients with a positive PCa family history and higher age should be considered for PCa diagnostic procedures.Conclusion: Blood samples can be considered for PCA3 evaluating as a promising alternative of urine samples for PCa diagnosis.


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