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CASE REPORT
Year : 2020  |  Volume : 7  |  Issue : 1  |  Page : 41-44

Mantle cell lymphoma presented as cryoglobulinemic vasculitis


1 Division of Hematology and Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital, Chiayi and Chang Gung University College of Medicine, Taoyuan, Taiwan
2 Department of Dermatology, Chang Gung Memorial Hospital, Kaohsiung and Chang Gung University College of Medicine, Taoyuan, Taiwan

Correspondence Address:
Dr. Chang-Hsien Lu
Division of Hematology and Oncology, Department of Internal Medicine, Chang Gung Memorial Hospital at Chiayi, No. 6, W. Sec., Chiapu Rd., Putzu City, Chiayi 61363
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCRP.JCRP_28_19

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Mantle cell lymphoma (MCL) is an uncommon subtype of B-cell lymphoproliferative neoplasm which often presents as lymphadenopathy or organomegaly. Herein, we present the case of a 69-year-old male who developed the rapid onset of cyanotic digits and nose. Cryoglobulin was detected, and a skin biopsy showed occlusive vasculopathy, which suggested cryoglobulinemic vasculitis. A bone marrow biopsy confirmed the diagnosis of cyclin D1-negative, SOX11-positive MCL. He received systemic immunochemotherapy including bortezomib and rituximab, and his cryoglobulinemia completely resolved. In addition, his lymphoma remains in complete remission 2 years after the diagnosis.


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