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CASE REPORT
Year : 2020  |  Volume : 7  |  Issue : 2  |  Page : 90-94

A neurofibromatosis type I patient presenting with four different cancer types including malignant peripheral nerve sheath tumor, gastrointestinal stromal tumor, pancreatic neuroendocrine tumor, and renal cell carcinoma within 1 year


1 Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
2 Department of Pathology, National Taiwan University Hospital, Taipei, Taiwan
3 Department of Oncology, National Taiwan University Hospital; Graduate Institute of Oncology, National Taiwan University College of Medicine; National Taiwan Unversity Cancer Center, Taipei, Taiwan

Correspondence Address:
Dr. Tom Wei-Wu Chen
Department of Oncolgoy, National Taiwan University Hospital, No. 7 Chung-shan South Rd., Taipei
Taiwan
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/JCRP.JCRP_2_20

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Neurofibromatosis type 1 (NF1) is a germline autosomal dominant disorder caused by the loss-of-function tumor suppressor gene NF1, which encodes neurofibromin protein. When multiple tumors arise within a short time in patients with the germline NF1 mutation, it is important to determine whether the tumors are metastatic or different primary tumors. We, herein, report a 35-year-old female with multiple tumors that were confirmed to be a malignant peripheral nerve sheath tumor, gastrointestinal stromal tumor, renal cell carcinoma, and pancreatic neuroendocrine tumor, and all were treated accordingly. This case further supports that tissue confirmation is important in patients with the NF1 germline mutation.


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