Journal of Cancer Research and Practice

CASE REPORT
Year
: 2019  |  Volume : 6  |  Issue : 2  |  Page : 85--88

A Patient with refractory metastatic germ cell tumor successful salvaged after treatment with paclitaxel, ifosfamide, and high-dose 5-Fluorouracil infusional therapy


Keng-Man Chiang1, Ann-Lii Cheng2 
1 Department of Oncology, National Taiwan University Hospital, Taipei, Taiwan
2 Department of Oncology; Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

Correspondence Address:
Dr. Keng-Man Chiang
Department of Oncology, National Taiwan University Hospital, No. 7, Zhongshan South Road, Taipei 10002
Taiwan

We report a case of a 24-year-old male with a metastatic extragonadal germ cell tumor (GCT) which was refractory to conventional chemotherapy and progressed after high-dose chemotherapy. The addition of a 24-h infusion of high-dose 5-fluorouracil (5-FU) with leucovorin regimen to a salvage regimen of paclitaxel and ifosfamide provided a durable clinical response. We also discuss the potential of repurposing 5-FU for the treatment of a refractory GCT.


How to cite this article:
Chiang KM, Cheng AL. A Patient with refractory metastatic germ cell tumor successful salvaged after treatment with paclitaxel, ifosfamide, and high-dose 5-Fluorouracil infusional therapy.J Cancer Res Pract 2019;6:85-88


How to cite this URL:
Chiang KM, Cheng AL. A Patient with refractory metastatic germ cell tumor successful salvaged after treatment with paclitaxel, ifosfamide, and high-dose 5-Fluorouracil infusional therapy. J Cancer Res Pract [serial online] 2019 [cited 2020 Jan 23 ];6:85-88
Available from: http://www.ejcrp.org/article.asp?issn=2311-3006;year=2019;volume=6;issue=2;spage=85;epage=88;aulast=Chiang;type=0