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  Indian J Med Microbiol
 

Figure 1: Biogenesis of mature microRNA. The microRNAs gene undergoes transcription by the RNA polymerase II to form the pri-microRNA that will be cleaved into pre-microRNA by Drosha. The pre-microRNA will be then exported out of the nucleus into the cytoplasm by the protein exportin-5. The pre-microRNA will be cleaved by Dicer, to form a MicroRNAs duplex consisting of a passenger strand and a mature microRNAs. The passenger strand will be degraded, whereas the mature microRNAs mediates gene-silencing processes by targeting specific messenger RNAs

Figure 1: Biogenesis of mature microRNA. The microRNAs gene undergoes transcription by the RNA polymerase II to form the pri-microRNA that will be cleaved into pre-microRNA by Drosha. The pre-microRNA will be then exported out of the nucleus into the cytoplasm by the protein exportin-5. The pre-microRNA will be cleaved by Dicer, to form a MicroRNAs duplex consisting of a passenger strand and a mature microRNAs. The passenger strand will be degraded, whereas the mature microRNAs mediates gene-silencing processes by targeting specific messenger RNAs